The Early Evolution of Primordial Pair-Instability Supernovae

The observational signatures of the first cosmic explosions and their chemical imprint on second-generation stars both crucially depend on how heavy elements mix within the star at the earliest stages of the blast. We present numerical simulations of the early evolution of Population III pair-instability supernovae with the new adaptive mesh refinement code CASTRO. In stark contrast to 15 - 40 Msun core-collapse primordial supernovae, we find no mixing in most 150 - 250 Msun pair-instability supernovae out to times well after breakout from the surface of the star. This may be the key to determining the mass of the progenitor of a primeval supernova, because vigorous mixing will cause emission lines from heavy metals such as Fe and Ni to appear much sooner in the light curves of core-collapse supernovae than in those of pair-instability explosions. Our results also imply that unlike low-mass Pop III supernovae, whose collective metal yields can be directly compared to the chemical abundances of extremely metal-poor stars, further detailed numerical simulations will be required to determine the nucleosynthetic imprint of very massive Pop III stars on their direct descendants.Comment: submitted to ApJ, comments welcom

Generalised Umbral Moonshine

Umbral moonshine describes an unexpected relation between 23 finite groups arising from lattice symmetries and special mock modular forms. It includes the Mathieu moonshine as a special case and can itself be viewed as an example of the more general moonshine phenomenon which connects finite groups and distinguished modular objects. In this paper we introduce the notion of generalised umbral moonshine, which includes the generalised Mathieu moonshine [Gaberdiel M.R., Persson D., Ronellenfitsch H., Volpato R., Commun. Number Theory Phys. 7 (2013), 145-223] as a special case, and provide supporting data for it. A central role is played by the deformed Drinfel'd (or quantum) double of each umbral finite group $G$, specified by a cohomology class in $H^3(G,U(1))$. We conjecture that in each of the 23 cases there exists a rule to assign an infinite-dimensional module for the deformed Drinfel'd double of the umbral finite group underlying the mock modular forms of umbral moonshine and generalised umbral moonshine. We also discuss the possible origin of the generalised umbral moonshine

Addressing a global epidemic: Opportunities for adult education to assist suicide loss survivors

Globally 800,000 people die by suicide every year. The worldwide prevalence of suicide has led to an increase in suicide prevention educational programming, but suicide bereavement education is rarely addressed. The upward trend of suicide rates has direct implications at the personal, community, societal, and global levels. The purpose of this literature review is to bring together empirical studies of those bereaved by suicide from various fields, so that researchers in adult education have a direction for this much-needed area of exploration. Three themes emerged during this research: (a) unique bereavement challenges, (b) barriers to obtaining support, and (c) sources of effective support. The studies were conducted in the fields of death and dying, mental health, public health, nursing, and suicidology with only one study conducted in the field of adult education. The results of this literature review can serve as a starting point for synergistic endeavors between adult education researchers and scholars in these fields to create programing that will serve the needs of suicide loss survivors. Such endeavors will bridge the gap between adult education theories and praxis

Hexabromocyclododecane decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells

Hexabromocyclododecane (HBCD) is a flame retardant that decreases the lytic function of human natural killer (NK) cells. NK cells defend against tumor cells and virally infected cells. Thus, HBCD has the potential to increase cancer incidence and viral infections. NK cells must bind to their targets for lysis to occur. Thus, concentrations of HBCD that decrease lytic function were examined for their ability to alter NK binding to tumor targets. Levels of HBCD that caused a loss of binding function were examined for effects on expression of cell surface proteins needed for binding. NK cells exposed to HBCD for 24 h, 48 h or 6 days or to HBCD for 1 h followed by 24 h, 48 h or 6 days in HBCD-free media were examined for binding function and cell surface protein expression. The results indicated that exposure of NK cells to 10 μM HBCD for 24 h (which caused a greater than 90% loss of lytic function) caused a very significant decrease in NK cell binding function (70.9%), and in CD16 and CD56 cell-surface protein expression (57.8 and 24.6% respectively). NK cells exposed to 10 μM HBCD for 1 h followed by 24 h in HBCD-free media (which caused a 89.3% loss of lytic function) showed decreased binding function (79.2%), and CD 16 expression (48.1%). Results indicate that HBCD exposures decreased binding function as well as cell-surface marker expression in NK cells and that these changes may explain the losses of lytic function induced by certain HBCD exposures

Hexabromocyclododecane decreases the lytic function and ATP levels of human natural killer cells

This study investigates the effect of hexabromocyclododecane (HBCD) on the lytic function of human natural killer (NK) cells and on ATP levels in NK cells. NK cells are capable of lysing tumor cells, virally infected cells, and antibody-coated cells. HBCD is a brominated cyclic alkane used primarily as an additive flame retardant. If HBCD interferes with NK cell function, this could increase risk of tumor development and/or viral infection. NK cells were exposed to various concentrations of HBCD for 24 and 48 h and 6 days before determining lytic function and ATP levels. ATP levels and lytic function were also determined in NK cells that were exposed to HBCD for 1 h followed by 24 and 48 h, and 6 days in HBCD-free media. The results indicated that exposure of NK cells to 10 µm HBCD for 24 h causes a very significant decrease in both NK cell lytic function and ATP levels (93.5 and 90.5%, respectively). Exposure of NK cells to 10 µm HBCD for 1 h followed by 24 h in HBCD-free media showed a progressive and persistent loss of lytic function (89.3%) as well as a decrease in ATP levels (46.1%). The results indicate that HBCD exposures decreased lytic function as well as ATP levels. However, a decrease in lytic function was not necessarily accompanied by a similar decrease in ATP. Importantly, these results also indicate that a brief (1 h) exposure to HBCD causes a progressive loss of lytic function over a 6 day period

How the First Stars Regulated Star Formation. II. Enrichment by Nearby Supernovae

Metals from Population III (Pop III) supernovae led to the formation of less massive Pop II stars in the early universe, altering the course of evolution of primeval galaxies and cosmological reionization. There are a variety of scenarios in which heavy elements from the first supernovae were taken up into second-generation stars, but cosmological simulations only model them on the largest scales. We present small-scale, high-resolution simulations of the chemical enrichment of a primordial halo by a nearby supernova after partial evaporation by the progenitor star. We find that ejecta from the explosion crash into and mix violently with ablative flows driven off the halo by the star, creating dense, enriched clumps capable of collapsing into Pop II stars. Metals may mix less efficiently with the partially exposed core of the halo, so it might form either Pop III or Pop II stars. Both Pop II and III stars may thus form after the collision if the ejecta do not strip all the gas from the halo. The partial evaporation of the halo prior to the explosion is crucial to its later enrichment by the supernova.Comment: Accepted to Ap